New bronchodilator aerosol preparations.

New bronchodilator aerosol preparations.

Correspondence MBIRrNAL 421 hysteria or to altered xnedical perception in the community. Their erroneous conclusions about this illness may impair future investigations of similar outbreaks. It is apparent that the authors failed to do their homework, and demonstrated a surprising lack of information about the principles of epidemiology and of psychiatry. Had they reviewed the literature on the...

Bronchodilator delivery from Gentlehaler, a new low-velocity pressurized aerosol inhaler.

We have compared radioaerosol deposition pattern and bronchodilator response following inhalation of 100 micrograms of albuterol from a correctly used conventional metered dose inhaler (MDI) to those from Gentlehaler, a new compact low-velocity pressurized aerosol device (Schering Corporation), in a group of ten asthmatic patients (mean baseline FEV1 52 percent; reversibility > 15 percent). Who...

Bitolterol mesylate (WIN 32784) aerosol. A new long-acting bronchodilator with reduced chronotropic effects.

Bitolterol mesylate (WIN 37284) is alpha-[tert-butylaminomethyl]-3,4-dihydroxybenzyl alcohol 3,4-di(p-toluate) methanesulfonate, a diester sympathomimetic amine bronchodilator. Bitolterol mesylate represents a new concept in sympathomimetic amine therapy. It is "prodrug" which is inactive until altered in the body. The intact 3,4-diester molecule is metabolized by esterase hydrolysis to release...

Clinical assessment of bronchodilator drugs delivered by aerosol.

Comparison of the Bronchodilator Effects of Aerosol Fenoterol and lsoproterenol*

Aerosolized fenoterol in a dosage of 400 g was compared to Isoproterenol 150 g in 31 asthmatic subjects during the course of a double-blind parallel 90-day study. Bronchodilator activities of the two drugs were evaluated for up to 6 hours on days 1, 45 and 90. Analysis of the data revealed that fenoterol consistently produced a significantly greater increase in FEy1, FEF25-75% and Gaw/YL. Speci...